101 Theory Drive: A Neuroscientist's Quest for Memory MOBI

101 Theory Drive: A Neuroscientist's Quest for Memory MOBI

101 Theory Drive: A Neuroscientist's Quest for Memory [PDF / Epub] ☀ 101 Theory Drive: A Neuroscientist's Quest for Memory By Terry McDermott – Capitalsoftworks.co.uk An obsessive scientist and his eclectic team of researchers race to discover one of the hidden treasures of neuroscience the physical makeup of memory and in the process pursue a pharmaceutical wonder Drive: A Kindle Ö An obsessive scientist and his eclectic team of researchers race to discover one of the hidden treasures of neuroscience the physical makeup of memory and in the process pursue a pharmaceutical wonder drugGary Lynch is the real thing, the epitome of the rebel scientist malnourished, contentious, inspiring, explosive, remarkably ambitious, and consistently brilliant He is one 101 Theory PDF or of the foremost figures of contemporary neuroscience, and his decades long quest to understand the inner workings of the brain s memory machine has begun to pay off Award winning journalist Terry McDermott spent nearly two years observing Lynch at work and now gives us a fascinating and dramatic account of daily life in his lab the Theory Drive: A PDF/EPUB ¼ highs and lows, the drudgery and eureka moments, the agonizing failures He provides detailed, lucid explanations of the cutting edge science that enabled Lynch to reveal the inner workings of the molecular machine that manufactures memory After establishing the building blocks, Lynch then set his sights on uncovering the complicated structure of memory as it is stored across many neurons Adding practical significance to his groundbreaking work, Lynch discovered a class of drugs that could fix the memory machine when it breaks, drugs that would enhance brain function during the memory process and that hold out the possibility of cures for a wide range of neurological conditions, including Alzheimer s disease, Parkinson s disease, and attention deficit hyperactivity disorder Here is an essential story of science, scientists, and scientific achievement galvanizing in the telling and thrilling in its far reaching implications.


About the Author: Terry McDermott

Drive: A Kindle Ö Terry McDermott is the author of Perfect Soldiers HarperCollins, , and Theory Drive Pantheon, His work has appeared in The New Yorker, The Smithsonian, Columbia Journalism Review, the Los Angeles Times Magazine and Pacific Magazine McDermott worked at eight newspapers forthan thirty years, most recently for ten years at the Los Angeles Times, 101 Theory PDF or where he was a national correspondent.



10 thoughts on “101 Theory Drive: A Neuroscientist's Quest for Memory

  1. Kent Winward Kent Winward says:

    One of the best neuroscience related books I ve read, largely because it clarifies in ways rarely done, just how very little we understand about the brain and how it operates We don t have memory chips and no one is quite sure how we remember things And no one really wants to write or read books about what we don t know Each advance is only climbing a ridge to see an evendistant and vast expanse Meanwhile, the economics drives the scientists to cooperate with pharmaceutical companie One of the best neuroscience related books I ve read, largely because it clarifies in ways rarely done, just how very little we understand about the brain and how it operates We don t have memory chips and no one is quite sure how we remember things And no one really wants to write or read books about what we don t know Each advance is only climbing a ridge to see an evendistant and vast expanse Meanwhile, the economics drives the scientists to cooperate with pharmaceutical companies to create drugs from each speck of light that might peak through on some type of theory on how our brains actually work Not encouraging if you are looking for neurological breakthroughs, but enlightening


  2. Peter Rogers Peter Rogers says:

    If you are interested in the science of memory, this is a great book.Author follows the research of UC Irvine, neuroscientist Gary Lynch for years as his group makes discovery after discovery.Gary Lynch is an aggressive, arrogant genius.That is actually common.When I was at Stanford and Harvard, I met some geniuses that were like that.They are a lot of fun Some people don t like them because they are nonconformist But is part of their nonconformity that motivates them to pursue new scientifi If you are interested in the science of memory, this is a great book.Author follows the research of UC Irvine, neuroscientist Gary Lynch for years as his group makes discovery after discovery.Gary Lynch is an aggressive, arrogant genius.That is actually common.When I was at Stanford and Harvard, I met some geniuses that were like that.They are a lot of fun Some people don t like them because they are nonconformist But is part of their nonconformity that motivates them to pursue new scientific ideas.Gary Lynch has lots of clever, funny quotes The discoveries on the path to understanding long term potentiation and long term memory are discussed in considerable entertaining detail


  3. Tom Schulte Tom Schulte says:

    This is the amazing tale of Gary Lynch, am obsessive, driven, Scotch loving neuroscientist at UC Irvine His lab studies memory and, apparently, has made important discoveries This book covers his research into long term potentiation in memory a persistent strengthening of synapses based on recent patterns of activity It is both exciting and some what disheartening to learn of the awesome potential of human memory identified in intracellular calcium transients left over from primitive olfacto This is the amazing tale of Gary Lynch, am obsessive, driven, Scotch loving neuroscientist at UC Irvine His lab studies memory and, apparently, has made important discoveries This book covers his research into long term potentiation in memory a persistent strengthening of synapses based on recent patterns of activity It is both exciting and some what disheartening to learn of the awesome potential of human memory identified in intracellular calcium transients left over from primitive olfactory evolution This science history work seems to fit along with theoretical physics advances where the actual underpinnings arecomplex than expected the hippocampus directing memory tasks to various brain areas , the there there being so seemingly insignificant phosphorylation a chemical reaction in which a small phosphate group is added to another molecule to change that molecule s activity


  4. Taylor Taylor says:

    101 Theory Drive was a genuinely enjoyable experience Though I must admit that much of it was over my head, the author did a good job of making the information scientific and otherwise attainable, and packed in a good deal of character development from a personal and interactive level The feeling of joining these scientists on their quest for memory is tangible in the pages, andthan one reader will be surprised to see the personalities behind the lab coats, as they deviate greatly fr 101 Theory Drive was a genuinely enjoyable experience Though I must admit that much of it was over my head, the author did a good job of making the information scientific and otherwise attainable, and packed in a good deal of character development from a personal and interactive level The feeling of joining these scientists on their quest for memory is tangible in the pages, andthan one reader will be surprised to see the personalities behind the lab coats, as they deviate greatly from what has grown to be the perceived standard for scientists across the country Their rebel attitudes and odd lifestyles greatly enhance the experience I only wish I could rememberof it


  5. Leif Denti Leif Denti says:

    We follow the excentric scientist Gary Lynch and his work on the mechanisms of memory Continuously throughout the book we are being told that his work is resisted by other scientists, but the book portrays Lynch as the misunderstood hero rather than actually showing the counter arguments by other scientists Thus I felt that the book was a bit biased toward Lynch s line of work and I could never really figure out whether or not his work was is valuable.


  6. Seth Seth says:

    A bit crass and rambling, and altogether fun.


  7. Eric Bengtson Eric Bengtson says:

    I would give this book a 3.5 if possible, but 4 seems too high I don t like the character but the depth of science is pretty good.


  8. rabbitprincess rabbitprincess says:

    An illuminating look at one scientist s decades long quest to find the actual physical indication of memory in the brain It s written relatively clearly, but you have to sit down with it for extended periods of time if you want to engage the theta rhythm and activate long term potentiation LTP , both of which are discussed in this book, thereby retaining what you learn from its pages.The titular neuroscientist, Gary Lynch, is a colourful character He came to neuroscience from a completely dif An illuminating look at one scientist s decades long quest to find the actual physical indication of memory in the brain It s written relatively clearly, but you have to sit down with it for extended periods of time if you want to engage the theta rhythm and activate long term potentiation LTP , both of which are discussed in this book, thereby retaining what you learn from its pages.The titular neuroscientist, Gary Lynch, is a colourful character He came to neuroscience from a completely different academic background and essentially taught himself biology His lab is filled with a multidisciplinary team that I think really brings home the benefits of having a wide ranging education For example, one of the lab members was a computer programmer before turning to neuroscience Later on, the team needed a computer program to sort through mounds and mounds of data on rat hippocampi, and commercially available software wasn t cutting it, so this guy wrote his own program to do the job Very impressive, not to mention handy.The team s successes and failures are interesting to read about, and you really appreciate just how much work goes into all of those experiments, and how gratifying it is to see one s experiments turn out successfully Even so, the scientists of Lynch Lab are very pragmatic, usually refusing to believe what they see until they ve repeated the experiment umpteen times Because their goal is to be able to point at a spot in the brain and say, There That s memory, they don t want to get carried away with themselves and pin too much false hope on a result.One of the most fascinating things I learned from this book was that the brain has a built in forgetting process that erases most of what you experience Makes sense, because you don t want to remember literally every single detail of every single day If you did, and the Lynch team were able to make all of those memories physically visible in your cerebral cortex, it would look like the synapse version of the show Hoarders So essentially what the researchers have discovered is that aging and the memory decline associated therewith is basically the forgetting process being stronger than LTP, so they just need to find a way to block the forgetting process and or boost the remembering process, and they ll have made great strides in the fight against Alzheimer s, Parkinson s, Huntington s, and other cognitive decline diseases There are even diseases that don t necessarily have a cognitive component but exhibit the same problems with LTP.I ve also learned that memory research is a cruel mistress, especially for the poor rats sacrificed to the cause the image of a headless rat twitching in a garbage can is rather horrifying So if you re an animal lover, be warned The description doesn t really go beyond that it s justthinking about the sheer number of rats that have been killed over the years for these studies.As I stated earlier, this book is fairly accessible, and the author draws some very clever comparisons e.g that humans are PCs see Chapter 13 and uses other common subjects such as baseball to illustrate the memory concepts at work The book also includes a glossary of terms and a selected bibliography of the actual papers if you re interested I would recommend this book to well informed laymen and those with a specialized interest in this kind of field


  9. Dav Dav says:

    This was a fascinating biography of an unusual scientist, Gary Lynch I happen to know a few neuroscientists and the most curious things about reading this was how much certain portions of his personality reminded me of them and how none of them had ever heard of him The latter is odd because if this book is to be believed, Lynch is perhaps the greatest neuroscientist of our times easier to say if you consider his arch nemesis not really Eric Kandel to be of a previous time, which he kind of This was a fascinating biography of an unusual scientist, Gary Lynch I happen to know a few neuroscientists and the most curious things about reading this was how much certain portions of his personality reminded me of them and how none of them had ever heard of him The latter is odd because if this book is to be believed, Lynch is perhaps the greatest neuroscientist of our times easier to say if you consider his arch nemesis not really Eric Kandel to be of a previous time, which he kind of is.I learned a lot about the physiology of the brain from this book,so than my previous favorite book about the brain, On Intelligence, which presented a great theory of how intelligence works, butof a software engineering description than a biological chemical description In this book we not only get down into the nitty gritty of cellular and molecular interaction, but we get to ride along with the scientists as they make the discoveries themselves.I m not sure what to make of this book really I have to admit I m seduced by the character of Lynch He s a Delillo Pynchon reading hard partying but hard working in your face autodidact with a disdain for Ivy Leaguers who tends to be always right in the face of constant doubt and bad luck If I were going to be a scientist, I d never be any better than that and wouldn t care to be So the fact that my neuroscientist friends haven t heard of him makes me wonder if it s all just a tale spun by an entertaining author.I m going to get one of them to read it and let me know, so I ll update this review then


  10. Chris Chris says:

    This is an incredibly dense book and not one suitable for audio, at least for me While it says it is a biography of Gary Lynch, noted neuroscientist, it is just as much a biography of his life s work Which, I guess in a case like this, makes a lot of sense Problem is, I am not a scientist, let alone anything to do with neuroscience, so much of the science stuff went way over my head I got some of it, but I think going into this book it would help immensely to have a background in the field, This is an incredibly dense book and not one suitable for audio, at least for me While it says it is a biography of Gary Lynch, noted neuroscientist, it is just as much a biography of his life s work Which, I guess in a case like this, makes a lot of sense Problem is, I am not a scientist, let alone anything to do with neuroscience, so much of the science stuff went way over my head I got some of it, but I think going into this book it would help immensely to have a background in the field, at least remotely It s not like a science journal essay, but some of it does get about as dry as a textbook I did enjoy some of the writing about Lynch himself, along with the others in his lab and field of study He has done some pretty amazing work His character is quite a mad genius, which keeps it fairly interesting I also enjoyed some of the look into how the politics of the field of science works Everything from working with the university to getting their papers published in peer reviewed journals So much backstabbing and fights I can see how someone like Lynch would get immensely frustrated The final lines were spot on, how the narrator mentions that he just will never see the end There is alwaysto discover, learn, and study I may have gottenfrom a paper version, but not that much It probably doesn t help when I listen to a slightly sped up narration, but the narrator was good for the most part


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10 thoughts on “101 Theory Drive: A Neuroscientist's Quest for Memory

  1. Kent Winward Kent Winward says:

    One of the best neuroscience related books I ve read, largely because it clarifies in ways rarely done, just how very little we understand about the brain and how it operates We don t have memory chips and no one is quite sure how we remember things And no one really wants to write or read books about what we don t know Each advance is only climbing a ridge to see an evendistant and vast expanse Meanwhile, the economics drives the scientists to cooperate with pharmaceutical companie One of the best neuroscience related books I ve read, largely because it clarifies in ways rarely done, just how very little we understand about the brain and how it operates We don t have memory chips and no one is quite sure how we remember things And no one really wants to write or read books about what we don t know Each advance is only climbing a ridge to see an evendistant and vast expanse Meanwhile, the economics drives the scientists to cooperate with pharmaceutical companies to create drugs from each speck of light that might peak through on some type of theory on how our brains actually work Not encouraging if you are looking for neurological breakthroughs, but enlightening

  2. Peter Rogers Peter Rogers says:

    If you are interested in the science of memory, this is a great book.Author follows the research of UC Irvine, neuroscientist Gary Lynch for years as his group makes discovery after discovery.Gary Lynch is an aggressive, arrogant genius.That is actually common.When I was at Stanford and Harvard, I met some geniuses that were like that.They are a lot of fun Some people don t like them because they are nonconformist But is part of their nonconformity that motivates them to pursue new scientifi If you are interested in the science of memory, this is a great book.Author follows the research of UC Irvine, neuroscientist Gary Lynch for years as his group makes discovery after discovery.Gary Lynch is an aggressive, arrogant genius.That is actually common.When I was at Stanford and Harvard, I met some geniuses that were like that.They are a lot of fun Some people don t like them because they are nonconformist But is part of their nonconformity that motivates them to pursue new scientific ideas.Gary Lynch has lots of clever, funny quotes The discoveries on the path to understanding long term potentiation and long term memory are discussed in considerable entertaining detail

  3. Tom Schulte Tom Schulte says:

    This is the amazing tale of Gary Lynch, am obsessive, driven, Scotch loving neuroscientist at UC Irvine His lab studies memory and, apparently, has made important discoveries This book covers his research into long term potentiation in memory a persistent strengthening of synapses based on recent patterns of activity It is both exciting and some what disheartening to learn of the awesome potential of human memory identified in intracellular calcium transients left over from primitive olfacto This is the amazing tale of Gary Lynch, am obsessive, driven, Scotch loving neuroscientist at UC Irvine His lab studies memory and, apparently, has made important discoveries This book covers his research into long term potentiation in memory a persistent strengthening of synapses based on recent patterns of activity It is both exciting and some what disheartening to learn of the awesome potential of human memory identified in intracellular calcium transients left over from primitive olfactory evolution This science history work seems to fit along with theoretical physics advances where the actual underpinnings arecomplex than expected the hippocampus directing memory tasks to various brain areas , the there there being so seemingly insignificant phosphorylation a chemical reaction in which a small phosphate group is added to another molecule to change that molecule s activity

  4. Taylor Taylor says:

    101 Theory Drive was a genuinely enjoyable experience Though I must admit that much of it was over my head, the author did a good job of making the information scientific and otherwise attainable, and packed in a good deal of character development from a personal and interactive level The feeling of joining these scientists on their quest for memory is tangible in the pages, andthan one reader will be surprised to see the personalities behind the lab coats, as they deviate greatly fr 101 Theory Drive was a genuinely enjoyable experience Though I must admit that much of it was over my head, the author did a good job of making the information scientific and otherwise attainable, and packed in a good deal of character development from a personal and interactive level The feeling of joining these scientists on their quest for memory is tangible in the pages, andthan one reader will be surprised to see the personalities behind the lab coats, as they deviate greatly from what has grown to be the perceived standard for scientists across the country Their rebel attitudes and odd lifestyles greatly enhance the experience I only wish I could rememberof it

  5. Leif Denti Leif Denti says:

    We follow the excentric scientist Gary Lynch and his work on the mechanisms of memory Continuously throughout the book we are being told that his work is resisted by other scientists, but the book portrays Lynch as the misunderstood hero rather than actually showing the counter arguments by other scientists Thus I felt that the book was a bit biased toward Lynch s line of work and I could never really figure out whether or not his work was is valuable.

  6. Seth Seth says:

    A bit crass and rambling, and altogether fun.

  7. Eric Bengtson Eric Bengtson says:

    I would give this book a 3.5 if possible, but 4 seems too high I don t like the character but the depth of science is pretty good.

  8. rabbitprincess rabbitprincess says:

    An illuminating look at one scientist s decades long quest to find the actual physical indication of memory in the brain It s written relatively clearly, but you have to sit down with it for extended periods of time if you want to engage the theta rhythm and activate long term potentiation LTP , both of which are discussed in this book, thereby retaining what you learn from its pages.The titular neuroscientist, Gary Lynch, is a colourful character He came to neuroscience from a completely dif An illuminating look at one scientist s decades long quest to find the actual physical indication of memory in the brain It s written relatively clearly, but you have to sit down with it for extended periods of time if you want to engage the theta rhythm and activate long term potentiation LTP , both of which are discussed in this book, thereby retaining what you learn from its pages.The titular neuroscientist, Gary Lynch, is a colourful character He came to neuroscience from a completely different academic background and essentially taught himself biology His lab is filled with a multidisciplinary team that I think really brings home the benefits of having a wide ranging education For example, one of the lab members was a computer programmer before turning to neuroscience Later on, the team needed a computer program to sort through mounds and mounds of data on rat hippocampi, and commercially available software wasn t cutting it, so this guy wrote his own program to do the job Very impressive, not to mention handy.The team s successes and failures are interesting to read about, and you really appreciate just how much work goes into all of those experiments, and how gratifying it is to see one s experiments turn out successfully Even so, the scientists of Lynch Lab are very pragmatic, usually refusing to believe what they see until they ve repeated the experiment umpteen times Because their goal is to be able to point at a spot in the brain and say, There That s memory, they don t want to get carried away with themselves and pin too much false hope on a result.One of the most fascinating things I learned from this book was that the brain has a built in forgetting process that erases most of what you experience Makes sense, because you don t want to remember literally every single detail of every single day If you did, and the Lynch team were able to make all of those memories physically visible in your cerebral cortex, it would look like the synapse version of the show Hoarders So essentially what the researchers have discovered is that aging and the memory decline associated therewith is basically the forgetting process being stronger than LTP, so they just need to find a way to block the forgetting process and or boost the remembering process, and they ll have made great strides in the fight against Alzheimer s, Parkinson s, Huntington s, and other cognitive decline diseases There are even diseases that don t necessarily have a cognitive component but exhibit the same problems with LTP.I ve also learned that memory research is a cruel mistress, especially for the poor rats sacrificed to the cause the image of a headless rat twitching in a garbage can is rather horrifying So if you re an animal lover, be warned The description doesn t really go beyond that it s justthinking about the sheer number of rats that have been killed over the years for these studies.As I stated earlier, this book is fairly accessible, and the author draws some very clever comparisons e.g that humans are PCs see Chapter 13 and uses other common subjects such as baseball to illustrate the memory concepts at work The book also includes a glossary of terms and a selected bibliography of the actual papers if you re interested I would recommend this book to well informed laymen and those with a specialized interest in this kind of field

  9. Dav Dav says:

    This was a fascinating biography of an unusual scientist, Gary Lynch I happen to know a few neuroscientists and the most curious things about reading this was how much certain portions of his personality reminded me of them and how none of them had ever heard of him The latter is odd because if this book is to be believed, Lynch is perhaps the greatest neuroscientist of our times easier to say if you consider his arch nemesis not really Eric Kandel to be of a previous time, which he kind of This was a fascinating biography of an unusual scientist, Gary Lynch I happen to know a few neuroscientists and the most curious things about reading this was how much certain portions of his personality reminded me of them and how none of them had ever heard of him The latter is odd because if this book is to be believed, Lynch is perhaps the greatest neuroscientist of our times easier to say if you consider his arch nemesis not really Eric Kandel to be of a previous time, which he kind of is.I learned a lot about the physiology of the brain from this book,so than my previous favorite book about the brain, On Intelligence, which presented a great theory of how intelligence works, butof a software engineering description than a biological chemical description In this book we not only get down into the nitty gritty of cellular and molecular interaction, but we get to ride along with the scientists as they make the discoveries themselves.I m not sure what to make of this book really I have to admit I m seduced by the character of Lynch He s a Delillo Pynchon reading hard partying but hard working in your face autodidact with a disdain for Ivy Leaguers who tends to be always right in the face of constant doubt and bad luck If I were going to be a scientist, I d never be any better than that and wouldn t care to be So the fact that my neuroscientist friends haven t heard of him makes me wonder if it s all just a tale spun by an entertaining author.I m going to get one of them to read it and let me know, so I ll update this review then

  10. Chris Chris says:

    This is an incredibly dense book and not one suitable for audio, at least for me While it says it is a biography of Gary Lynch, noted neuroscientist, it is just as much a biography of his life s work Which, I guess in a case like this, makes a lot of sense Problem is, I am not a scientist, let alone anything to do with neuroscience, so much of the science stuff went way over my head I got some of it, but I think going into this book it would help immensely to have a background in the field, This is an incredibly dense book and not one suitable for audio, at least for me While it says it is a biography of Gary Lynch, noted neuroscientist, it is just as much a biography of his life s work Which, I guess in a case like this, makes a lot of sense Problem is, I am not a scientist, let alone anything to do with neuroscience, so much of the science stuff went way over my head I got some of it, but I think going into this book it would help immensely to have a background in the field, at least remotely It s not like a science journal essay, but some of it does get about as dry as a textbook I did enjoy some of the writing about Lynch himself, along with the others in his lab and field of study He has done some pretty amazing work His character is quite a mad genius, which keeps it fairly interesting I also enjoyed some of the look into how the politics of the field of science works Everything from working with the university to getting their papers published in peer reviewed journals So much backstabbing and fights I can see how someone like Lynch would get immensely frustrated The final lines were spot on, how the narrator mentions that he just will never see the end There is alwaysto discover, learn, and study I may have gottenfrom a paper version, but not that much It probably doesn t help when I listen to a slightly sped up narration, but the narrator was good for the most part

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